Detailed Mechanism Funding and Narrative

Years of mechanism: 2011 2012

Details for Mechanism ID: 13129
Country/Region: South Africa
Year: 2012
Main Partner: Foundation for Innovative New Diagnostics
Main Partner Program: NA
Organizational Type: NGO
Funding Agency: HHS/CDC
Total Funding: $1,000,000

FIND aims to strengthen the quality of laboratory services, introduce new and more rapid diagnostic tools, increase human resource capacity and support the integration of laboratory services for diagnostic testing of tuberculosis (TB), and HIV. FIND will support the National Health Laboratory Services NHLS South Africa to continue the roll out of the Xpert MTV/Rif (Cepheid) new test, recently endorsed by WHO, at an additional five high burden testing sites along with an appropriate EQA scheme at all already established testing sites. A recent study revealed variable compliance with some of the steps involved, ranging from patient verification (for TB sputum testing), to proper testing procedures, particularly with respect to biosafety (wearing gloves TB and HIV specimen collection), to reporting, and to referral back to the health care provider (HIV testing). The causes for non-compliance as identified in the study include: lack of training, lack of supplies (blood HIV testing and folders/registers TB), and deliberate staff error (not wearing gloves). Rectifying these issues will require a multifaceted approach including: i) review of training and training refresher procedures and materials; ii) record-keeping/administrative procedures (e.g. examining whether these could be simplified or automated to facilitate compliance); and iii) logistics (to ensure needed items are in stock).Working with the NHLS and the CDC, FIND will first identify activities that can be prioritized.. Procedures for monitoring to ensure process compliance, and quality improvement activities will be designed and implemented.

Funding for Laboratory Infrastructure (HLAB): $1,000,000

FIND will facilitate the implementation of Xpert/Rif testing at 5 high burden testing sites with training equipment and reagents with two technicians to be trained per site with the assay. FIND will also facilitate the wider roll-out and EQA of the Xpert/Rif assay for of rapid detection of drug resistant TB . This will include the development and piloting of an EQA scheme, building on the work already done by NHLS, the development of a computer-based monitoring system for Xpert/RIF which will support EQA, as well as system monitoring to provide timely feedback on quality indicators, corrective actions, testing capacity and benchmarking of testing sites.This will be planned to cover 10 sites in COP11, and in COP12, FIND will continue to support the NHLS with the phased implementation of the system to all testing sites. FIND will also assist the NHLS with revisions of training materials and SOPs for Xpert/Rif. In order to strengthen the clinical laboratory interface in the country FIND will work on the development of a mobile phone based system and software that will support improved processes for specimen collection, tracking and transportation. This will be linked to the in-built capacity of the Xpert device. In order to strengthen the clinical laboratory interface in the country FIND proposes to work on the development of a mobile phone based logistics improvement system and software. Improving the pre-analytic and post-analytic phases of laboratory services. FIND will work with NHLS and CDC to identify key areas , such as improving processes, redesigning recording requirements and forms, and providing selected trainings. Throughout all these activities, FIND will build on existing systems and work already done by the NHLS. In all these areas, FIND will carefully evaluate the current systems, and consult closely with NHLS and CDC.

Key Issues Identified in Mechanism
Workplace Programs